時間：2025年5月9日（周五）上午10:00
地點：武漢大學櫻頂老圖書館
主講人：程亦凡 美國藝術與科學院院士、美國國家科學院院士
題目：冷凍電鏡：歷史視角與未來挑戰
Cryo-EM: its historic perspectives and future challenges
主講人簡介：
程亦凡，美國藝術與科學院院士、美國國家科學院院士，武漢大學杰出校友（2020年）。現任霍華德·休斯醫學研究所（Howard Hughes Medical Institute, HHMI）研究員、加州大學舊金山分校（UCSF）生物化學與生物物理學系教授。
程亦凡實驗室專注于利用冷凍電鏡解析生物大分子結構，尤其是膜蛋白與動態復合物的分子機制。此外，開發冷凍電鏡技術以推動結構生物學發展也是其團隊的長期研究方向。實驗室的里程碑成果包括：開發校正電子束誘導圖像運動的算法，以及通過單顆粒冷凍電鏡技術首次解析了TRPV1離子通道的原子級結構等。
程亦凡博士將電子檢測相機引入冷凍電鏡技術，極大地推動了單粒子冷凍電鏡從低分辨率提升至原子結構測定，為該領域帶來了突破性的技術變革。發表 150 余篇論文及綜述文章，其中在《Nature》《Cell》《Science》等頂尖學術期刊上發表文章40 余篇。曾獲國際蛋白質學會頒發的克里斯蒂安·B·安芬森獎（2018年）
Brief Introduction of Professor Yifan Cheng
Dr. Yifan Cheng, a member of the American Academy of Arts and Sciences and the National Academy of Sciences, is a Distinguished Alumnus of Wuhan University (2020). He currently serves as an Investigator at the Howard Hughes Medical Institute (HHMI) and a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF).
The Cheng Laboratory focuses on using cryo-EM to resolve the structures of biological macromolecules, particularly integral membrane proteins and dynamic complexes. A long-standing goal of his team is the development of cryo-EM methodologies to advance structural biology. Landmark achievements include the development of algorithms to correct electron beam-induced image motion and the first atomic-resolution structure determination of the TRPV1 ion channel using single-particle cryo-EM. Throughout his career, Dr. Cheng has made transformative contributions to the field. By introducing electron-detecting cameras into cryo-EM technology, he dramatically advanced single-particle cryo-EM from low-resolution imaging to atomic-level structure determination, sparking a revolutionary breakthrough in the field. He has published over 150 research articles and reviews in leading life science journals, with over 40 appearing in top-tier journals such as Nature, Cell, and Science. He was awarded the Christian B. Anfinsen Award by the Protein Society in 2018.
承辦單位：武漢大學藥學院
邀請人：董長江
